The Synergistic Effect of Conditional Pten Loss and Oncogenic K-ras Mutation on Endometrial Cancer Development Occurs via Decreased Progesterone Receptor Action

Figure 4

Histology of uteri from mice with Pten ablation and oncogenic K-ras mutation. H&E staining of control, K-ras^G12D, Pten^d/d, and Pten^d/dK-ras^G12D mice at 2 and 4 weeks of age. Endometrial cancer was induced in the uteri of Pten^d/dK-ras^G12D mice, but not in other mice at 4 weeks of ages. Scale bar: 200 𝜇m.