Use of H19 Gene Regulatory Sequences in DNA-Based  Therapy for Pancreatic Cancer

<table class="table-group" id="tab1"><tr><td><table class="table"><tr><td class="thead-hr" colspan="4"><hr/></td></tr><tr class="thead"><td align="left">Group</td><td align="center">Animals with metastasis on day 7/total</td><td align="center">Animals with metastasis on day 9/total</td><td align="left">Animals with metastasis on day 11/total</td></tr><tr><td class="thead-hr" colspan="4"><hr/></td></tr><tr><td align="left"><b>DTA-H19</b></td><td align="center"><b>0/9</b></td><td align="center"><b>3/9</b></td><td align="left"><b>3/9 </b>Metastases in liver, stomach, or intestine (<svg height="7.1374998" id="M44" style="vertical-align:-0.10033pt" version="1.1" viewbox="0 0 7.8874998 7.1374998" width="7.8874998" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,7.1375)">
<g transform="translate(72,-66.29)">
<text transform="matrix(1,0,0,-1,-71.95,66.44)">
<tspan style="font-size: 12.50px; " x="0" y="0">𝑛</tspan>
</text>
</g>
</g>
</svg> <svg height="11.25" id="M45" style="vertical-align:-1.29163pt" version="1.1" viewbox="0 0 15.175 11.25" width="15.175" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,11.25)">
<g transform="translate(72,-63)">
<text transform="matrix(1,0,0,-1,-71.95,64.34)">
<tspan style="font-size: 12.50px; " x="0" y="0">≤</tspan>
</text>
</g>
</g>
</svg> 2)</td></tr><tr><td align="left"><b>Luc-H19 </b>(control group)</td><td align="center"><b>1/7</b></td><td align="center"><b>4/7</b></td><td align="left"><b>7/7 </b>Multiple abdominal metastases (<svg height="7.1374998" id="M46" style="vertical-align:-0.10033pt" version="1.1" viewbox="0 0 7.8874998 7.1374998" width="7.8874998" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,7.1375)">
<g transform="translate(72,-66.29)">
<text transform="matrix(1,0,0,-1,-71.95,66.44)">
<tspan style="font-size: 12.50px; " x="0" y="0">𝑛</tspan>
</text>
</g>
</g>
</svg><svg height="8.8500004" id="M47" style="vertical-align:-0.30096pt" version="1.1" viewbox="0 0 10.825 8.8500004" width="10.825" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,8.85)">
<g transform="translate(72,-64.92)">
<text transform="matrix(1,0,0,-1,-71.95,65.27)">
<tspan style="font-size: 12.50px; " x="0" y="0">&gt;</tspan>
</text>
</g>
</g>
</svg> 3)</td></tr><tr class="table-tr"><td colspan="4"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

Metastases observation developed in the hamster orthotopic pancreatic carcinoma model. Animals presenting pancreatic tumors were treated twice with DTA-H19 or Luc-H19 plasmids. Before each treatment, abdominal cavity was searched for metastases in both groups, the treated group DTA-H19 (<svg height="7.1374998" id="M42" style="vertical-align:-0.10033pt" version="1.1" viewbox="0 0 7.8874998 7.1374998" width="7.8874998" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,7.1375)">
<g transform="translate(72,-66.29)">
<text transform="matrix(1,0,0,-1,-71.95,66.44)">
<tspan style="font-size: 12.50px; " x="0" y="0">𝑛</tspan>
</text>
</g>
</g>
</svg> = 9) and the control group (<svg height="7.1374998" id="M43" style="vertical-align:-0.10033pt" version="1.1" viewbox="0 0 7.8874998 7.1374998" width="7.8874998" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,7.1375)">
<g transform="translate(72,-66.29)">
<text transform="matrix(1,0,0,-1,-71.95,66.44)">
<tspan style="font-size: 12.50px; " x="0" y="0">𝑛</tspan>
</text>
</g>
</g>
</svg> = 7). Most metastases appeared visible on day 9. 

Journal of Oncology

tab1

Table 1

Table 1: Use of H19 Gene Regulatory Sequences in DNA-Based  Therapy for Pancreatic Cancer 