Myeloid Cells in the Tumor Microenvironment: Modulation of Tumor Angiogenesis and Tumor Inflammation

Figure 2

Recruitment of diverse bone marrow-derived cell populations to the tumor microenvironment and their effects on tumor progression. Tumor and stromal cells mobilize various subpopulations of tumor promoting bone marrow-derived cells to the peripheral blood through secretion of cytokines and chemokines. Diverse chemoattractant factors promote the recruitment and infiltration of these cells to the tumor microenvironment where they suppress the antitumor immunity or promote tumor angiogenesis and vasculogenesis or raise refractoriness against anti-VEGF therapy.