Expression of Fatty Acid Synthase Depends on NAC1 and Is Associated with Recurrent Ovarian Serous Carcinomas
NAC1-dependent FASN expression in ovarian cancer cells. (a) N130 mRNA, as detected by a PCR primer pair that amplifies the N130 region, increases after N130 induction. In contrast, FASN mRNA decreases 48 and 72 hours after induction. (b) After shRNA lentivirus transduction, both shRNAs (-A and -C) effectively reduce NAC1 transcript levels to less than 10% of control and reduce FASN expression.
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