Expression of Fatty Acid Synthase Depends on NAC1 and Is Associated with Recurrent Ovarian Serous Carcinomas
Expression of NAC1 and FASN in ovarian tumor tissues. (a) Western blot analysis shows a single protein band that corresponds to FASN protein in all three ovarian cancer cell lines (OVCAR3, A2780, and SKOV3) but not in a low-grade serous carcinoma cell line (MPSC1) nor in ovarian surface epithelial cells (OSE10). (b) Immunoreactivity of NAC1 (upper panels) and FASN (bottom panels) in four representative high-grade serous carcinomas. For each staining, the immunostaining scores are shown in the upper left corner (c)-(d). FASN expression in different types of ovarian carcinomas. (c) FASN immunointensity scores for different types of ovarian carcinoma including high-grade serous, low-grade serous, clear cell, and endometrioid carcinomas. The mean and standard deviation of the immunostaining score are shown. (d) Representative tumor sections of FASN immunostaining are illustrated. FASN immunoreactivity is detectable in high-grade serous carcinoma cells but not in normal ovarian surface epithelium nor in cystadenomas.
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