Journal of Oncology / 2010 / Article / Fig 4

Research Article

Expression of Fatty Acid Synthase Depends on NAC1 and Is Associated with Recurrent Ovarian Serous Carcinomas

Figure 4

C93 treatment promotes apoptosis in ovarian cancer cells including cells that are resistant to carboplatin and paclitaxel. (a) In three ovarian cancer cell lines, C93 at its IC50 concentration increases the percentage of annexin V stained cells in a time dependent fashion. DMSO was used as the vehicle control. (b) C93 also increases annexin V stained cells in carboplatin resistant (CR) and paclitaxel resistant (TR) cell lines. (c) In all three cell lines, C93 treatment leads to an increase in sub-G1 cells when compared to the DMSO-treated group ( 𝑃 < . 0 0 1 ). The percentage of sub-G1 cells is measured 48 hours after C93 treatment.

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