Germline Mutations and Polymorphisms in the Origins of Cancers in Women

Table 1

Genetic loci implicated in hereditary, familial, and sporadic breast cancer susceptibility.

High penetrance,	Low penetrance,	Low penetrance,
low frequency	low frequency	High frequency
BRCA1	CHEK2	FGFR2
BRCA2	ATM	LSP1
PTEN	PALB2	MAP3K1
p53	BRIP1	TGFB1
STK11		TOX3
		2q35
		8q