Thyroid Cancer: Current Molecular Perspectives

Table 2

Prevalence of major genetic alterations in all of the TCs but MTC.

Genes	PTC	FTC	ATC
BRAF	45%	RARE	20%
RAS	10%–20%	40%–50%	50%–60%
NTRK1	<5%	—	—
PI3K/AKT and PTEN	—	7%	15%
TP53	RARE	RARE	60%–80%
CTNNB1	RARE	RARE	66%
RET/PTC	25%–30%	—	—
PAX8/PPAR𝛾	—	35%	—