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Journal of Oncology
Volume 2010, Article ID 372547, 16 pages
http://dx.doi.org/10.1155/2010/372547
Review Article

Antivascular Therapy for Epithelial Ovarian Cancer

1Centre du Cancer, Department of Medical Oncology, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, 1200 Brussels, Belgium
2F.R.S.-FNRS Research Fellow, Belgium

Received 27 May 2009; Accepted 28 September 2009

Academic Editor: Maurie M. Markman

Copyright © 2010 Francois P. Duhoux and Jean-Pascal Machiels. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Ovarian cancer is the fifth largest cancer killer in women. Improved understanding of the molecular pathways implicated in the pathogenesis of ovarian cancer has led to the investigation of novel targeted therapies. Ovarian cancer is characterized by an imbalance between pro- and antiangiogenic factors in favor of angiogenesis activation. Various antivascular strategies are currently under investigation in ovarian cancer. They can schematically be divided into antiangiogenic and vascular-disrupting therapies. This paper provides a comprehensive review of these new treatments targeting the tumor vasculature in this disease. Promising activities have been detected in phase II trials, and results of phase III clinical trials are awaited eagerly.