|
| Patients analyzed | Type of cancer | Method of CTC detection | Results | Reference |
|
| 53 esophageal cancer patients22 benign patients who underwent thoracotomy30 healthy volunteers | Esophageal cancer | (1) Density gradient separation (OncoQuick)(2) Real-time RT-PCR (CEA-based) | Patients with high levels of CTCs (CEA) were more likely to show recurrent disease | Liu et al. [43] |
| 62 esophageal cancer patients (25 SCC/37 EA) | Esophageal cancer | (1) Density gradient separation (OncoQuick)(2) Real-time RT-PCR (survivin-based) | Survivn mRNA levels fall after surgical resection | Hoffmann et al. [60] |
| 44 patients with GI malignancy -24 esophageal cancer -5 gastric cancer -8 colorectal cancer -3 pancreatic | GI malignancies | (1) Density gradient separation (OncoQuick)(2) Real-time RT-PCR (survivin-based) | Survivn mRNA levels fall after surgical resection | Hoffmann et al. [31] |
| 29 locally advanced esophageal cancer patients (11 SCC/18 EA) | Esophageal cancer | (1) Density gradient separation (OncoQuick)(2) Real-time RT-PCR (ERCC1-based) | ERCC1 mRNA expression associated with response to neoadjuvant radiochemotherapy | Brabender et al. [71] |
| 59 locally advanced esophageal cancer patients (24 SCC/35 EA) | Esophageal cancer | (1) Density gradient separation(2) Methylation specific real-time RT-PCR (DAPK and APC-based) | DAPK and APC methylation associated with unfavourable prognosis | Hoffmann et al. [44] |
| 57 gastric cancer patients15 patients with benign diseae15 healthy volunteers | Gastric cancer | (1) Density gradient separation(2) Real-time RT-PCR (CEA-based) | Patients with high levels of CTCs (CEA) were more likely to show recurrent disease | Miyazono et al. [63] |
| 59 gastric cancer patients15 patients with benign diseae | Gastric cancer | (1) CTC-enrichment was not performed(2) Real-time RT-PCR (CEA-based) | High levels of CEA were associated with lower risk of tumor recurrence | Ikeguchi et al. [64] |
| 430 mCRC patients beginning a new first-, second-, or third-line systemic therapy | Colorectal cancer | Immunomagnetic CTC enumeration (CellSearch, Veridex) | Patients with high CTCs had poor PFS and OS | Cohen et al. [66] |
| 430 mCRC patients beginning a new first-, second-, or third-line systemic therapy (follow-up study) | Colorectal cancer | Immunomagnetic CTC enumeration (CellSearch, Veridex) | Patients with high CTCs had poor PFS and OS (also within subgroups with longer follow up) | Cohen et al. [67] |
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