Repeated Intraperitoneal -Radioimmunotherapy of Ovarian Cancer in Mice
Table 1
Study groups and number of mice with macroscopic and microscopic tumors and ascites.
Group
n
Treatment
Number of treatments
Macroscopic tumors
Microscopic tumors
Ascites
1
18
-MX35 in
1
11/18
15/18
15/18
0.17
2
18
-MX35 in
2
16/18
16/18
8/18
0.11
3
18
-MX35 in PBS‡
3
11/18
11/18
5/18
0.39
4
18
-MX35 in
4
10/18
10/18
1/18
0.44
5
18
-MX35 in
5
10/18
10/18
0/18
0.44
6
18
-MX35 in
6
6/18
6/18
0/18
0.67
7
12
MX35 in PBS
1
12/12
12/12
10/12
0
tumor-free fraction (i.e., fraction of animals with no macro- and microscopic tumors and no ascites). Injected activities were ± 14 kBq (mean ± SEM). phosphate-buffered saline. The presence of macroscopic tumors and ascites was assesed by careful ocular inspection during dissection 2 mo after the last administration of the radioimmunocomplex. Microscopic tumor growth was assessed by conventional histopathology. Judgements were blinded from treatment information.