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Journal of Oncology
Volume 2010, Article ID 497429, 7 pages
http://dx.doi.org/10.1155/2010/497429
Review Article

Treatment for Recurrent Ovarian Cancer—At First Relapse

Department of OBGYN, Kurume University School of Medicine, 67 Asahi machi, Kurume 830-0011, Japan

Received 7 July 2009; Revised 27 September 2009; Accepted 15 October 2009

Academic Editor: Dennis S. Chi

Copyright © 2010 Kimio Ushijima. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Recurrent ovarian cancer is a lethal disease, and few patients can be cured. Although most patients receive standardized surgery and chemotherapy, the status of recurrent disease is heterogeneous. The site of recurrence and the survival intervals after recurrence are also widely distributed. Among a number of factors, many clinical trials identified time to recurrence was the factor most related to chemosensitivity at first relapse. The current recommendation for platinum sensitive ovarian cancer is a carboplatin containing combination chemotherapy. Generally, a single agent is chosen for platinum resistant ovarian cancer. Patients with single site recurrence and a long disease free interval are candidates for secondary cytoreduction, which may provide longer survival. There are several treatment choices at first relapse, and disease status, chemotherapy-free interval, and the patient's condition play a major role in the decision making process.