Small-Area Analysis of Incidence and Localisation of Vulvar Cancer
Table 1
Data of 104 patients with vulvar cancer treated between 1994 and 2008. Figures give number of patients unless noted otherwise.
Cohort-1 (1994–1998)
Cohort-2 (1999–2003)
Cohort-3 (2004–2008)
Number
11
21
72
Mean age [years]
73.18
58.90
61.19
95% CI [years]
64.04; 82.33
52.24; 65.57
57.27; 65.12
Age 50 years
1
7
20
Comorbidities: no
1
3
13
Tobacco abuse: yes
2
10
25
n.s.
Histology
Squamous cell
10
17
63
n.s.
Nonsqamous cell
1
4
Verrucous
1
1
1
Adenocarcinoma
2
Other
2
2
FIGO
I
2
4
30
n.s.
II
4
4
14
III
1
3
5
IV
3
7
X
4
7
16
Grading
G1
3
5
6
n.s.
G2
8
13
57
G3
6
G4
1
GX
3
1
Depth [mm] mean +/− SD
5.7 (2.1)
3.7 (4.9)
5.3 (5.4)
n.s.
VIN surrounding invasive cancer [%]
9.1
42.8
41.7
History of lichen sclerosus or carcinoma-in-situ [%]
45.5
33.3
20.8
n.s.
Unifocal lesion
1
7
35
ASA
n.s.
1
1
1
15
2
1
11
28
3
3
7
27
4
0
1
1
x
6
1
1
Surgery
Biopsy only
2
Wide excision or partial vulvectomy
5
11
59
Radical vulvectomy
6
8
13
Adjuvant radiation: yes
1
5
14
n.s.
Alive (May 2009)
Yes
6
20
72
No
1
Not known
5
CI = confidence interval. ASA = American Society of Anesthesiologists' Physical Status Classification. LNE = inguinal lymphadenectomy. SD = standard deviation. ANOVA (post-hoc comparisons with Games-Howell). Kruskal-Wallis test. Fisher’s exact test. Cohort-3 versus cohort-1. Cohort-2 versus cohort-1. Cohort-2 versus cohort-3.
