Locking Src/Abl Tyrosine Kinase Activities Regulate Cell Differentiation and Invasion of Human Cervical Cancer Cells Expressing E6/E7 Oncoproteins of High-Risk HPV

Figure 1

Effect of SKI-606 and Iressa on cell growth of HeLa human cervical cancer cells. We note that cell proliferation slightly relies on Src/Abl and EGF-R inhibitor concentrations at 2 and 5 𝜇M each; in contrast, Src/Abl inhibitor, but not EGF-R, drastically inhibits cell proliferation of HeLa and SiHa cells (data not shown) at 10 𝜇M. Bars, SDs of each point.