Claudin Family of Proteins and Cancer: An Overview

Figure 2

Schematic representation of structure of claudins. Claudins are transmembrane proteins with domains 1 to 4 (TMD-1, TMD-2, TMD-3, and TMD-4) and extracellular loops represent promising target for therapy. The –COOH terminal of claudins contains PDZ-binding domain which undergoes posttranscriptional modification that is important for signal transduction.