Claudin Family of Proteins and Cancer: An Overview

<table>Schematic representation of multiple mechanisms implicated in the regulation of the expression and function of claudins. Broken lines indicate indirect pathways and solid lines represent direct pathways. Abbreviations: HDAC-Histone deacetylase; MAPKs- mitogen-activated protein kinases; RUNX3—Runt-related transcription factor 3; FOXO1—Forkhead box O-1; PAR3/PAR6-Partitioning defective; PI3K- Phosphoinositide 3-kinases; <svg height="10.6375" id="M22" style="vertical-align:-0.13792pt" version="1.1" viewbox="0 0 25.35 10.6375" width="25.35" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,10.6375)">
<g transform="translate(72,-63.49)">
<text transform="matrix(1,0,0,-1,-71.95,63.67)">
<tspan style="font-size: 12.50px; " x="0" y="0">N</tspan>
<tspan style="font-size: 12.50px; " x="9.0271664" y="0">F</tspan>
<tspan style="font-size: 12.50px; " x="16.003839" y="0">-</tspan>
</text>
</g>
</g>
</svg><i>κ </i><svg height="10.475" id="M23" style="vertical-align:-0.0pt" version="1.1" viewbox="0 0 10.55 10.475" width="10.55" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,10.475)">
<g transform="translate(72,-63.62)">
<text transform="matrix(1,0,0,-1,-71.95,63.67)">
<tspan style="font-size: 12.50px; " x="0" y="0">B</tspan>
</text>
</g>
</g>
</svg> - nuclear factor kappa-light-chain-enhancer of activated B cells.</table>

Journal of Oncology

Claudin Family of Proteins and Cancer: An Overview

Figure 3