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Journal of Oncology
Volume 2010 (2010), Article ID 635984, 4 pages
Case Report

Hyperfunctioning Solid/Trabecular Follicular Carcinoma of the Thyroid Gland

1Department of Nuclear Medicine and PET-CT Centre, Oncology Institute of Southern Switzerland, 6500 Bellinzona, Switzerland
2Department of Surgery, Ente Ospedaliero Cantonale, Ospedale Regionale di Mendrisio, 6850 Mendrisio, Switzerland
3Department of Clinical Pathology, Cantonal Institute of Pathology, 6600 Locarno, Switzerland

Received 24 July 2009; Revised 14 May 2010; Accepted 17 June 2010

Academic Editor: Jennifer E. Rosen

Copyright © 2010 Luca Giovanella et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


A 68-year-old woman with solid/trabecular follicular thyroid carcinoma inside of an autonomously functioning thyroid nodule is described in this paper. The patient was referred to our clinic for swelling of the neck and an increased pulse rate. Ultrasonography showed a slightly hypoechoic nodule in the right lobe of the thyroid. Despite suppressed TSH levels, the 9 9 m T c -pertechnetate scan showed a hot area corresponding to the nodule with a suppressed uptake in the remaining thyroid tissue. Histopathological examination of the nodule revealed a solid/trabecular follicular thyroid carcinoma. To the best of our knowledge, this is the first case of hyperfunctioning follicular solid/trabecular carcinoma reported in the literature. Even if a hyperfunctioning thyroid carcinoma is an extremely rare malignancy, careful management is recommended so that a malignancy will not be overlooked in the hot thyroid nodules.