Thrombospondin-1 (TSP-1) Stimulates Expression of Integrin 6 in Human Breast Carcinoma Cells: A Downstream Modulator of TSP-1-Induced Cellular Adhesion
Figure 5
Anti-TSP-1 antibody inhibition of integrin 6 production in TSP-1 stably transfected cells. Cells were grown in six well chamber slides in either serum-free media or media containing either 10 g/mL control IgG or 10 g/mL goat antihuman TSP-1 IgG, fixed, and stained with rat 6 integrin IgG as described in Section 2. Cells were photographed at 200X magnification. (a) TH5 cells (vector control). (b) TH26 cells (high TSP-1 producer). (c) TH26 cells plus anti-TSP-1 antibody. (d) TH26 cells plus control IgG.
