Tumor Spreading to the Contralateral Ovary in Bilateral Ovarian Carcinoma Is a Late Event in Clonal Evolution
(a) All genomic imbalances detected by HR-CGH in 56 tumor lesions from altogether 32 cases of bilateral ovarian cancer (including six metastases to the omentum/peritoneum). (b) Genomic imbalances detected by HR-CGH in both tumorous ovaries from the 23 cases yielding informative results. The data from the latter subset are likely to reflect the earliest genomic changes, since they are present in both tumor lesions. Some of the imbalances in the former and larger group may have been acquired after spreading, since they also include findings in only one tumor per case.