Table of Contents Author Guidelines Submit a Manuscript
Journal of Oncology
Volume 2010, Article ID 736907, 10 pages
http://dx.doi.org/10.1155/2010/736907
Research Article

Significant Growth Inhibition of Canine Mammary Carcinoma Xenografts following Treatment with Oncolytic Vaccinia Virus GLV-1h68

1Genelux Corporation, San Diego Science Center, San Diego, CA 92109, USA
2Department of Biochemistry, University of Wuerzburg, 97074 Wuerzburg, Germany
3Center for Human Genetics, University of Bremen, 28359 Bremen, Germany
4Small Animal Clinic, University of Veterinary Medicine, Bischofsholer Damm 15, 30173 Hannover, Germany
5Rudolf Virchow Center for Experimental Biomedicine, University of Wuerzburg, 97078 Wuerzburg, Germany
6Institute for Molecular Infection Biology, University of Wuerzburg, 97078 Wuerzburg, Germany
7Department of Radiation Oncology, Moores Cancer Center, University of California, San Diego, 3855 Health Sciences Drive 0843, La Jolla, CA 92093-0843, USA

Received 28 August 2009; Revised 18 February 2010; Accepted 11 May 2010

Academic Editor: Dominic Fan

Copyright © 2010 Ivaylo Gentschev et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. Mottolese, L. Morelli, U. Agrimi et al., “Spontaneous canine mammary tumors: a model for monoclonal antibody diagnosis and treatment of human breast cancer,” Laboratory Investigation, vol. 71, no. 2, pp. 182–187, 1994. View at Google Scholar · View at Scopus
  2. E. Hellmén, “Complex mammary tumours in the female dog: a review,” Journal of Dairy Research, vol. 72, pp. 90–97, 2005. View at Publisher · View at Google Scholar · View at Scopus
  3. K. Sorenmo, “Canine mammary gland tumors,” Veterinary Clinics of North America—Small Animal Practice, vol. 33, no. 3, pp. 573–596, 2003. View at Publisher · View at Google Scholar · View at Scopus
  4. M. J. V. Vähä-Koskela, J. E. Heikkilä, and A. E. Hinkkanen, “Oncolytic viruses in cancer therapy,” Cancer Letters, vol. 254, no. 2, pp. 178–216, 2007. View at Publisher · View at Google Scholar · View at Scopus
  5. A. M. Crompton and D. H. Kirn, “From ONYX-015 to armed vaccinia viruses: the education and evolution of oncolytic virus development,” Current Cancer Drug Targets, vol. 7, no. 2, pp. 133–139, 2007. View at Publisher · View at Google Scholar · View at Scopus
  6. T.-C. Liu, E. Galanis, and D. Kirn, “Clinical trial results with oncolytic virotherapy: a century of promise, a decade of progress,” Nature Clinical Practice Oncology, vol. 4, no. 2, pp. 101–117, 2007. View at Publisher · View at Google Scholar · View at Scopus
  7. R. Cattaneo, T. Miest, E. V. Shashkova, and M. A. Barry, “Reprogrammed viruses as cancer therapeutics: targeted, armed and shielded,” Nature Reviews Microbiology, vol. 6, no. 7, pp. 529–540, 2008. View at Publisher · View at Google Scholar · View at Scopus
  8. D. H. Kirn and S. H. Thorne, “Targeted and armed oncolytic poxviruses: a novel multi-mechanistic therapeutic class for cancer,” Nature Reviews Cancer, vol. 9, no. 1, pp. 64–71, 2009. View at Publisher · View at Google Scholar · View at Scopus
  9. A. Worschech, D. Haddad, D. F. Stroncek, E. Wang, F. M. Marincola, and A. A. Szalay, “The immunologic aspects of poxvirus oncolytic therapy,” Cancer Immunology, Immunotherapy, vol. 58, no. 9, pp. 1355–1362, 2009. View at Publisher · View at Google Scholar · View at Scopus
  10. Q. Zhang, Y. A. Yu, E. Wang et al., “Eradication of solid human breast tumors in nude mice with an intravenously injected light-emitting oncolytic vaccinia virus,” Cancer Research, vol. 67, no. 20, pp. 10038–10046, 2007. View at Publisher · View at Google Scholar · View at Scopus
  11. K. J. Kelly, Y. Woo, P. Brader et al., “Novel oncolytic agent GLV-1h68 is effective against malignant pleural mesothelioma,” Human Gene Therapy, vol. 19, no. 8, pp. 774–782, 2008. View at Publisher · View at Google Scholar · View at Scopus
  12. I. Gentschev, J. Stritzker, E. Hofmann et al., “Use of an oncolytic vaccinia virus for the treatment of canine breast cancer in nude mice: preclinical development of a therapeutic agent,” Cancer Gene Therapy, vol. 16, no. 4, pp. 320–328, 2009. View at Publisher · View at Google Scholar · View at Scopus
  13. Y. A. Yu, C. Galanis, Y. Woo et al., “Regression of human pancreatic tumor xenografts in mice after a single systemic injection of recombinant vaccinia virus GLV-1h68,” Molecular Cancer Therapeutics, vol. 8, no. 1, pp. 141–151, 2009. View at Publisher · View at Google Scholar · View at Scopus
  14. S.-F. Lin, D. L. Price, C.-H. Chen et al., “Oncolytic vaccinia virotherapy of anaplastic thyroid cancer in vivo,” Journal of Clinical Endocrinology and Metabolism, vol. 93, no. 11, pp. 4403–4407, 2008. View at Publisher · View at Google Scholar · View at Scopus
  15. S.-F. Lin, Z. Yu, C. Riedl et al., “Treatment of anaplastic thyroid carcinoma in vitro with a mutant vaccinia virus,” Surgery, vol. 142, no. 6, pp. 976–983, 2007. View at Publisher · View at Google Scholar · View at Scopus
  16. K. A. Sterenczak, S. Willenbrock, M. Barann et al., “Cloning, characterisation, and comparative quantitative expression analyses of receptor for advanced glycation end products (RAGE) transcript forms,” Gene, vol. 434, no. 1-2, pp. 35–42, 2009. View at Publisher · View at Google Scholar · View at Scopus
  17. S. Weibel, J. Stritzker, M. Eck, W. Goebel, and A. A. Szalay, “Colonization of experimental murine breast tumours by Escherichia coli K-12 significantly alters the tumour microenvironment,” Cellular Microbiology, vol. 10, no. 6, pp. 1235–1248, 2008. View at Publisher · View at Google Scholar · View at Scopus
  18. I. Gentschev, U. Donat, E. Homann et al., “Regression of human prostate tumors and metastases in nude mice following treatment with the recombinant oncolytic vaccinia virus GLV-1h68,” Journal of Biomedicine and Biotechnology, vol. 2010, Article ID 489759, 11 pages, 2010. View at Publisher · View at Google Scholar · View at Scopus
  19. A. Worschech, N. Chen, Y. A. Yu et al., “Systemic treatment of xenografts with vaccinia virus GLV-1h68 reveals the immunologic facet of oncolytic therapy,” BMC Genomics, vol. 10, article 301, 2009. View at Publisher · View at Google Scholar · View at Scopus