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Journal of Oncology
Volume 2010, Article ID 740472, 9 pages
http://dx.doi.org/10.1155/2010/740472
Review Article

Targeted Therapy in Ovarian Cancer

Chao Family Comprehensive Cancer Center, University of California Irvine, Orange, CA 92868, USA

Received 9 July 2009; Revised 5 November 2009; Accepted 10 November 2009

Academic Editor: Charles F. Levenback

Copyright © 2010 Lyndsay J. Willmott and John P. Fruehauf. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Ovarian cancer is the most common cause of mortality of tumors from gynecologic origin and is often diagnosed after patients have already progressed to advanced disease stage. The current standard of care for treatment of ovarian cancer includes cytoreductive surgery followed by adjuvant chemotherapy. Unfortunately, many patients will recur and ultimately die from their disease. Targeted therapies have been evaluated in ovarian cancer as a method to overcome resistant disease. Angiogenesis inhibitors have shown success in many tumor types and have also demonstrated promise in trials involving patients with ovarian cancer. PARP inhibitors may be potentially active agents in patients with BRCA-associated ovarian cancer. Trials that have evaluated combinations of targeted agents have often revealed untoward toxicities, thus tempering enthusiasm for this approach.