Review Article

Molecular Abnormalities in Ovarian Cancer Subtypes Other than High-Grade Serous Carcinoma

Figure 3

Results of sequencing of the transcriptome of a granulosa cell tumor, showing sequence from the FOXL2 gene (a). At nucleotide 402, both G and C were identified, indicating that this tumor was hemizygous for the 402C->G mutation charateristic of adult-type granulosa tumor. Granulosa tumor cell nuclei show high-level expression of the FOXL2 protein by immunostaining (b), in association with this mutation.
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(a)
740968.fig.003b
(b)