Molecular Abnormalities in Ovarian Cancer Subtypes Other than High-Grade Serous Carcinoma
Figure 3
Results of sequencing of the transcriptome of a granulosa cell tumor, showing sequence from the FOXL2 gene (a). At nucleotide 402, both G and C were identified, indicating that this tumor was hemizygous for the 402C-G mutation charateristic of adult-type granulosa tumor. Granulosa tumor cell nuclei show high-level expression of the FOXL2 protein by immunostaining (b), in association with this mutation.