Effects of HIF-1𝛼 and HIF2𝛼 on Growth and Metabolism of Clear-Cell Renal Cell Carcinoma 786-0 Xenografts

Figure 3

(x100 hpf). Growth and death markers in CCRCC 786-0 tumors. (a–d) Ki67 proliferation index (${}^{*}P=.0006$). (e–h) Cyclin D1 expression (${}^{*}P=.001$). (i–l) Apoptosis as measured by cleaved-caspase-3% index (${}^{*}P=.0002$). (m–p) BNIP3 expression (cytoplasm only) (${}^{*}P=.0002$). ${}_{}{}^{*}P$ values were calculated using ANOVA test.

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