Loss of miR-200c: A Marker of Aggressiveness and Chemoresistance in Female Reproductive Cancers

Figure 2

Increased miR-200c decreases migration and invasion, not necessarily dependent on restoration of E-cadherin. Migration (a) and invasion (b) assays for MDA-MB-231 cells stably expressing an shRNA targeting ZEB1 with representative images below. Migration (c) and invasion (d) assays in Hey cells transiently transfected with a miR-200c mimic. Asterisks indicate a statistically significant difference ($P<.05$, Student’s $t$-test) versus negative controls.

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