Breast Carcinoma Cells in Primary Tumors and Effusions Have Different Gene Array Profiles
Table 2
Pathways involved in the differentially expressed genes (a): six individual effusion patients against the pooled sample of primary tumors; (b): 11 individual effusions against 11 individual primary tumors.
(a)
Pathway name
Number of genes in pathway
Number of differentially expressed genes in pathway
Percentage of differentially expressed genes in pathway
P-value
Cell adhesion molecules (CAMs)
132
10
7.576
1.36E-04
Regulation of actin cytoskeleton
208
11
5.288
0.001462
Focal adhesion
195
9
4.615
0.010329
Calcium signaling pathway
175
8
4.571
0.01545
ECM-receptor interaction
87
6
6.897
0.005234
Tight junction
119
4
3.361
0.175458
PPAR signaling pathway
70
3
4.286
0.123277
TGF-beta signaling pathway
84
1
1.19
0.780451
Wnt signaling pathway
149
1
0.671
0.935266
Apoptosis
84
1
1.19
0.792465
mTOR signaling pathway
47
1
2.128
0.584796
Gap junction
92
1
1.087
0.81801
MAPK signaling pathway
256
3
1.172
0.855694
Adherens junction
77
1
1.299
0.763346
Small cell lung cancer
86
1
1.163
0.800108
Cytokine-cytokine receptor interaction
256
1
0.391
0.990004
(b)
Pathway name
Number of genes in pathway
Number of differentially expressed genes in pathway
Percentage of differentially expressed genes in pathway
