Table 2: Pathways involved in the differentially expressed genes (a): six individual effusion patients against the pooled sample of primary tumors; (b): 11 individual effusions against 11 individual primary tumors.
(a)

Pathway nameNumber of genes in pathwayNumber of differentially expressed genes in pathwayPercentage of differentially expressed genes in pathwayP-value

Cell adhesion molecules (CAMs)132107.5761.36E-04
Regulation of actin cytoskeleton208115.2880.001462
Focal adhesion19594.6150.010329
Calcium signaling pathway17584.5710.01545
ECM-receptor interaction8766.8970.005234
Tight junction11943.3610.175458
PPAR signaling pathway7034.2860.123277
TGF-beta signaling pathway8411.190.780451
Wnt signaling pathway14910.6710.935266
Apoptosis8411.190.792465
mTOR signaling pathway4712.1280.584796
Gap junction9211.0870.81801
MAPK signaling pathway25631.1720.855694
Adherens junction7711.2990.763346
Small cell lung cancer8611.1630.800108
Cytokine-cytokine receptor interaction25610.3910.990004

(b)

Pathway nameNumber of genes in pathwayNumber of differentially expressed genes in pathwayPercentage of differentially expressed genes in pathwayP-value

Cell adhesion molecules (CAMs)13296.8184.22E-07
Regulation of actin cytoskeleton20841.9230.061989
Focal adhesion19531.5380.169683
ECM-receptor interaction8722.2990.130698
Tight junction11910.840.580383
TGF-beta signaling pathway8455.9523.19E-04
Wnt signaling pathway14932.0130.09173
Apoptosis8411.190.46079
mTOR signaling pathway4712.1280.291965
MAPK signaling pathway25631.1720.288211
Adherens junction7711.2990.432252
Small cell lung cancer8644.6510.003658
Cytokine-cytokine receptor interaction25641.5630.10534
Phosphatidylinositol signaling system7722.5970.106703
Pancreatic cancer7334.110.016395
Colorectal cancer8533.5290.023709
Cell cycle11432.6320.050093
Jak-STAT signaling pathway15331.9610.097521
Non-small cell lung cancer5323.7740.057405
Endometrial cancer5223.8460.055498
Basal cell carcinoma5623.5710.059335
Renal cell carcinoma6922.8990.09072
Melanoma7122.8170.09521
ErbB signaling pathway8722.2990.133163
Melanogenesis10221.9610.166065
Thyroid cancer3113.2260.203583
VEGF signaling pathway7011.4290.397797
Prostate cancer8611.1630.468679