The Role of Prophylactic Central Neck Dissection in Differentiated Thyroid Carcinoma: Issues and Controversies

Table 2

A comparison of cancer-specific mortality between those who underwent a total thyroidectomy and prophylactic neck dissection (CND+ group) and those who underwent a total thyroidectomy only (CND− group).

First author/year	Number of patients	Followup duration (months)	Cancer-specific mortality	P value	First author/year	Number of patients
	CND+ group	CND− group		CND+ group	CND− group
Tisell/1996 [28]	195	199 [62]; 167 [63]	156 months; (median)	1.6%	8.4%–11.1%	Not reported
Sywak/2006 [5]	P-56, A	391	CND−: 70 months; CND+: 25 months; (median)	0%	0%	Not significant
Roh/2007 [23]	P-40, B; T-42 (26/42 with lateral neck dissection)	73	52 months; (mean)	0%	0%	Not significant

CND−: thyroidectomy alone, CND+: thyroidectomy plus central neck dissection; P: prophylactic, T: therapeutic; A: unilateral, B: bilateral.