The Role of Prophylactic Central Neck Dissection in Differentiated Thyroid Carcinoma: Issues and Controversies

Table 3

A comparison of recurrence rates between those who underwent a total thyroidectomy and prophylactic neck dissection (CND+ group) and those who underwent a total thyroidectomy only (CND− group).

Study design	First author/year	Number of patients		Followup (mean)	Overall recurrence		P value
		CND+ group	CND− group		CND+ group	CND− group
Retrospective	Gemsenjäger/2003 [58]	P-29	88	8.1 years	3.4%	2.3%	Not mentioned
Retrospective	Wada/2003 [57]	P-235	155	53 months	0.4%	0.6%	Not significant
Retrospective	Sywak/2006 [5]	P-56, A	391	CND−: 70 months; CND+: 24.5 months; (median)	3.6%	5.6%	Not mentioned
Retrospective	Roh/2007 [23]	P-40, B; T-42, B	73	52 months	P-0%; T-1.2%	4.0%	Not mentioned
Retrospective	Zungia/2009 [65]	P-136,B	130	6.9 years	5 yr DFS-88.2%	5 yr DFS-85.6%	0.72
Retrospective	Costa/2009 [67]	P-126, B	118	CND−: 64 months; CND+: 47 months	6.3%	7.7%	0.83
Retrospective	Moo/2010 [24]	P-45, B	36	3.1 years	4.4%	16.7%	0.13
Meta-analysis	Zetoune/2010 [66]	P-396, A/B	868		2.0%	3.9%	NS
Retrospective	Lang/2011 [8]	P-82, A	103	26 months (median)	3.7%	2.9%	1.0

P: prophylactic, T: therapeutic; A: unilateral, B: bilateral; 5 yr DFS: 5-year disease-free survival.