Short-Term Exposure to Tobacco Toxins Alters Expression of Multiple Proliferation Gene Markers in Primary Human Bronchial Epithelial Cell Cultures

Table 2

N : C ratios at 24-hour carcinogen exposure compared to vehicle controls.

Carcinogen	N : C ratio at high dose	N : C ratio at med dose	N : C ratio at low dose
Nickel sulphate	0.338 (0.033)	0.318 (0.032)	0.196 (0.034)
	𝑃=.002	𝑃=.017	𝑃=.042
Chromium chloride	0.300 (0.031)	0.365 (0.033)	0.370 (0.033)
	NS	𝑃<.05	𝑃<.05
Benzo(b)fluoranthene	0.360 (0.034)	0.242 (0.033)	0.253 (0.033)
	𝑃<.05	NS	NS
Indeno(1,2,3,-cd)pyrene	0.184 (0.046)	0.248 (0.033)	0.209 (0.034)
	𝑃=.03	NS	NS
Ethyl carbamate	0.254 (0.029)	0.273 (0.028)	0.254 (0.028)
	NS	NS	NS
N-Nitrosodiethylamine	0.285 (0.028)	0.276 (0.028)	0.214 (0.029)
	NS	NS	NS
NNK	0.283 (0.032)	0.319 (0.035)	0.260 (0.032)
	NS	𝑃=.009	NS

NS: not statistically significant (𝑃≥.05).