Aberrant E-cadherin expression and formation of a late stage neoplasm. (a) Symmetrical CSC division within the early stage neoplasm results in multiple CSCs within the neoplastic population. (b) Restoration of E-cadherin expression within the CSCs and TACs leads to their reestablishment within the epithelium, loss of stem cell-like properties and formation of a neoplasm of latent tumorigenicity. (c) Alternatively, cellular proliferation continues unabated resulting in a late stage neoplasm comprising CSCs and TACs.