Loss of Function of E-Cadherin in Embryonic Stem Cells and the Relevance to Models of Tumorigenesis

<table><i>Diagrammatic representation of homophilic E-cadherin interaction and homotypic cell adhesion within the epithelium.</i> E-cadherin cis-dimers form transhomodimers with E-cadherin molecules on neighbouring cells to facilitate epithelial integrity. Note that the exact mechanism of homophilic E-cadherin interaction is unclear. For clarity, only E-cadherin is represented within adherens junctions.</table>

Journal of Oncology

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Figure 1

Figure 1: Loss of Function of E-Cadherin in Embryonic Stem Cells and the Relevance to Models of Tumorigenesis 