Loss of Function of E-Cadherin in Embryonic Stem Cells and the Relevance to Models of Tumorigenesis

<table><i>LIF signal transduction in mouse ES cells.</i> Following the binding of LIF to the heterodimeric LIFR/gp130 complex, the Jak/STAT3 and PI3K/Akt signalling pathways are activated which regulate expression of Sox2 and Nanog via Klf4 and Tbx3, respectively.</table>

Journal of Oncology

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Figure 4

Figure 4: Loss of Function of E-Cadherin in Embryonic Stem Cells and the Relevance to Models of Tumorigenesis 