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Journal of Oncology
Volume 2011, Article ID 391564, 6 pages
http://dx.doi.org/10.1155/2011/391564
Research Article

HER-2 Evaluation in a Specific Gastric Cancer Population with the Highest Rate of Mortality in Spain

1Oncology Department, Clinical University Hospital, 47005 Valladolid, Spain
2Pathology Department, Clinical University Hospital, 47005 Valladolid, Spain

Received 13 February 2011; Revised 21 August 2011; Accepted 5 September 2011

Academic Editor: Dirk Rades

Copyright © 2011 E. U. Cidon et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Gastric cancer (GC) still represents the second cause of cancer-related death worldwide. Radical resection is the mainstay of early stages treatment with little impact on overall survival (OS) in the advanced ones. HER-2 is the most relevant biological factor involved. Purpose. This study aims to show the relationship between HER-2 positivity and survival in patients with completely resected GC. Methods. Retrospective study of GC patients diagnosed in 2003–2005 at our institution. Surgical specimens underwent immunohistochemistry (IHC), and in cases +/++/+++ samples underwent also fluorescence in situ hybridisation (FISH) analyses of HER-2 and graduated according to experts' consensus. Results. 120 cases included. Overall expression detected in 7.5%. Correlation between HER-2 positive and female sex, advanced stages or histological grades, or intestinal type was detected. Early recurrences higher in HER-2 positive (66.6% versus 35.4%, 𝑃 = 0 . 0 4 8 ). The median DFS for c-erbB-2 positive was 15 months (range 2–67 months), and OS was 25 months (range 10–67 months). In the case of patients with c-erbB-2, negative median DFS was 27 months (range 5–67 months) and OS for this sample is 47 months (range 29–67 months). Conclusions. These results emphasize the relevance of HER-2 positivity in GC as independent prognostic factor and support its current analyses in daily practice.