Research Article
HER-2 Evaluation in a Specific Gastric Cancer Population with the Highest Rate of Mortality in Spain
Table 1
Immunohistochemistry scoring for HER2 in gastric and gastrooesophageal junction cancer, by type of diagnostic specimen.
| IHC | Surgical specimen | Biopsy specimen | HER2 overexpression interpretation |
| 0 | No reactivity or membranous reactivity in <10% of tumour cells | No reactivity or no membranous reactivity in any tumour cell | Negative |
| + | Faint or barely perceptible membranous reactivity in ≥10% of tumour cells; cells are reactive only in part of their membrane | Tumour cell cluster with a faint or barely perceptible membranous reactivity irrespective of percentage of tumour cells stained | Negative |
| ++ | Weak to moderate complete, basolateral, or lateral membranous reactivity in ≥10% of tumour cells | Tumour cell cluster with a weak to moderate complete, basolateral, or lateral membranous reactivity irrespective of percentage of tumour cells stained | Equivocal |
| +++ | Strong complete, basolateral, or lateral membranous reactivity in ≥10% of tumour cells | Tumour cell cluster with a strong complete, basolateral, or lateral membranous reactivity irrespective of percentage of tumour cells stained | Positive |
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