Mitochondrial DNA Content Varies with Pathological Characteristics of Breast Cancer
Table 1
Correlation of mtDNA content in breast cancer with clinicopathological features.
mtDNA content in tumor tissue
T/N ratio of mtDNA content
n
Mean ± SD
P value*
Mean ± SD
P value*
Age (years)
<40
56
592 ± 530
0.861 ± 0.561
40–49
103
588 ± 473
0.603
0.967 ± 0.7
0.817
50–59
77
0.956 ± 0.92
≥60
57
577 ± 402
0.956 ± 0.849
Tumor size (cm3)
(versus C)
(versus C)
A: ≤4.9
79
735 ± 412
1.088 ± 0.636
B: 5~14.9
66
574 ± 354
1.000 ± 0.556
C: 15–49.9
75
372 ± 248
0.696 ± 0.459
D: ≥50
53
535 ± 385
0.306
0.818 ± 0.553
0.258
Grade
0~I
18
669 ± 412
0.995 ± 0.681
II
125
506 ± 318
0.019 (versus 0~I)
0.791 ± 0.531
0.827 (versus 0~I)
III
98
648 ± 432
0.383 (versus 0~I) 0.006 (versus II)
1.128 ± 0.988
0.441 (versus 0~I) 0.033 (versus II)
ER
Negative
107
502 ± 405
0.103
0.810 ± 0.612
0.047
Positive
157
573 ± 374
1.057 ± 1.059
PR
Negative
100
494 ± 352
0.061
0.839 ± 0.633
0.059
Positive
154
597 ± 384
1.034 ± 0.772
ER/PR
A:ER,PR both − or either +
134
473 ± 316
0.005
0.837 ± 0.536
0.355
B: ER+/PR+
129
618 ± 381
0.930 ± 0.617
Her2/neu receptor
Negative
56
444 ± 333
0.101
0.727 ± 0.518
0.023
Positive
168
531 ± 346
1.127 ± 1.184
values are from Mann-Whitney or Kruskal-Wallis test. The values <0.05 are in bold, indicating significance; the values >0.05, but <0.15 are in italic, indicating weak significance.
