Mitochondrial DNA Content Varies with Pathological Characteristics of Breast Cancer
Table 3
Univariate and multivariate COX regression survival analysis.
Variables
Group
n
Univariate
Multivariate
HR (95% CI)
P value
HR (95% CI)
P value
Grade
0–II
68
1.00
1.00
III
35
2.65 (1.22–5.74)
0.014
2.48 (1.12–5.51)
0.025
Size (CM3)
<15
62
1.00
1.00
≥15
73
3.01 (1.42–6.37)
0.004
2.51 (0.96–6.55)
0.060
Age (Years)
<50
78
1.00
1.00
≥50
70
1.76 (0.94–3.30)
0.076
3.75 (1.44–9.75)
0.007
mtDNA Content in Tumor
<400
50
2.17 (1.03–4.55)
0.042
3.39 (1.17–9.82)
0.025
400–600
55
1.00
1.00
>600
43
1.37 (0.59–3.16)
0.463
4.05 (1.27–12.87)
0.018
Stage
0-I
14
1.00
II
62
1.67 (0.38–7.36)
0.397
III-IV
18
7.10 (1.57–32.18)
0.011
The values <0.05 are in bold, indicating significance; the values >0.05, but <0.10 are in italic, indicating weak significance. HR: hazard ratio; 95% CI: 95% confidence interval.
