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Journal of Oncology
Volume 2011, Article ID 525976, 5 pages
Research Article

Smoking, Alcohol, and Betel Quid and Oral Cancer: A Prospective Cohort Study

1Department of Otolaryngology, Taichung Veterans General Hospital, Chung-Kang Road, Taichung 40705, Taiwan
2Graduate Institute of Integrated Medicine, China Medical University, Taichung 40402, Taiwan
3Faculty of Medicine, School of Medicine, National Yang-Ming University, Taipei 11221, Taiwan

Received 10 December 2010; Accepted 21 January 2011

Academic Editor: Venkateshwar Keshamouni

Copyright © 2011 Wen-Jiun Lin et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


We aimed to investigate the association between smoking, alcoholic consumption, and betel quid chewing with oral cancer in a prospective manner. All male patients age ≥18 years who visited our clinic received an oral mucosa inspection. Basic data including personal habits were also obtained. A multivariate logistic regression model was utilized to determine relevant risk factors for developing oral cavity cancer. A total of 10,657 participants were enrolled in this study. Abnormal findings were found in 514 participants (4.8%). Three hundred forty-four participants received biopsy, and 230 patients were proven to have oral cancer. The results of multivariate logistic regression found that those who smoked, consumed alcohol, and chewed betel quid on a regular basis were most likely to develop cancer (odds ratio: 46.87, 95% confidence interval: 31.84–69.00). Therefore, habitual cigarette smokers, alcohol consumers, and betel quid chewers have a higher risk of contracting oral cancer and should receive oral screening regularly so potential oral cancer can be detected as early as possible.