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Journal of Oncology
Volume 2011 (2011), Article ID 549181, 10 pages
http://dx.doi.org/10.1155/2011/549181
Review Article

Lung Cancer Stem Cell: New Insights on Experimental Models and Preclinical Data

Laboratoire UPRES EA 27-10 “Radiosensibilité des Tumeurs et Tissus Sains”, Institut Gustave Roussy, 39 rue Camille Desmoulins, 94800 Villejuif, France

Received 1 October 2010; Accepted 15 November 2010

Academic Editor: Bo Lu

Copyright © 2011 Caroline Rivera et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Lung cancer remains the leading cause of cancer death. Understanding lung tumors physiopathology should provide opportunity to prevent tumor development or/and improve their therapeutic management. Cancer stem cell (CSC) theory refers to a subpopulation of cancer cells, also named tumor-initiating cells, that can drive cancer development. Cells presenting these characteristics have been identified and isolated from lung cancer. Exploring cell markers and signaling pathways specific to lung CSCs may lead to progress in therapy and improve the prognosis of patients with lung cancer. Continuous efforts in developing in vitro and in vivo models may yield reliable tools to better understand CSC abilities and to test new therapeutic targets. Preclinical data on putative CSC targets are emerging by now. These preliminary studies are critical for the next generation of lung cancer therapies.