Prevalence of Epithelial Ovarian Cancer Stem Cells Correlates with Recurrence in Early-Stage Ovarian Cancer

Figure 5

Association of EOC stem cells with stroma. (a-b) Ck18+ EOC stem cells are in close contact with the surrounding stroma (arrows); (c) a cluster of Ck18+ EOC stem cells are in close contact with the stroma forming a niche; (d) magnification of (c) showing the different cellular components: EOC stem cells (in red) in direct contact with the stroma and surrounded by Ck18-negative cancer cells. The arrow shows the basement membrane between the two compartments.