Familial Papillary Thyroid Carcinoma: A Retrospective Analysis

Table 4

Metastases and clinical course.

	Nonfamilial	1st Degree, 2 members	1st Degree, 3 or more members	P value
No. of patients	521	50	41
Cervical nodes positive	98 (18.8%)	12 (24.0%)	10 (24.4%)	0.27
Distant metastases	16 (3.1%)	2 (4.0%)	6 (14.6%)	0.003
Additional surgery	27 (5.2%)	2 (4.0%)	6 (14.6%)	0.05
Additional RAI >2 yrs after initial treatment	13 (2.5%)	4 (8.0%)	3 (7.3%)	0.03
Reoperation or additional RAI, 2 yrs after initial treatment	34 (6.5%)	6 (12.0%)	6 (14.6%)	0.03
Deaths due to disease	2 (0.4%)	1 (2.0%)	2 (4.9%)	0.01