Familial Papillary Thyroid Carcinoma: A Retrospective Analysis

Table 5

Selected data on history-defined families. Comparison of statistical analysis on history-defined and pathology-defined families.

	Nonfamilial	2nd degree or higher members	1st Degree, 2 members	1st Degree, 3 or more members	P-value history group	P-value pathology proven group
No. of patients	521	36	55	52
Tumour in perithyroidal tissue/thyroid Capsule penetration	87 (16.7%)	8 (22.2%)	9 (16.4%)	15 (28.8%)	0.08	0.17
Multifocal	272 (52.2%)	22 (61.1%)	36 (65.5%)	31 (59.6%)	0.06	0.34
Vascular/lymphatic invasion	58 (11.1%)	6 (16.7%)	8 (14.5%)	6 (11.5%)	0.56	0.73
Cervical nodes positive	98 (18.8%)	8 (22.2%)	15 (27.3%)	13 (25.0%)	0.10	0.27
Distant metastases	16 (3.1%)	2 (5.6%)	3 (5.5%)	7 (13.5%)	0.002	0.003
Deaths	2 (0.4%)	1 (2.1%)	1 (1.8%)	2 (3.1%)	0.02	0.01
Reoperation	27 (5.2%)	2 (5.6%)	2 (3.6%)	8 (15.4%)	0.03	0.05
RAI, Additional treatment, 2 years after initial treatment	13 (2.5%)	2 (5.6%)	4 (7.3%)	4 (7.7%)	0.01	0.03