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Journal of Oncology
Volume 2011 (2011), Article ID 953469, 8 pages
http://dx.doi.org/10.1155/2011/953469
Clinical Study

Oncogenic HPV Types Infection in Adolescents and University Women from North Portugal: From Self-Sampling to Cancer Prevention

1Molecular Oncology Group, Portuguese Institute of Oncology of Porto, Road Dr. António Bernardino Almeida, 4200-072 Porto, Portugal
2CEBIMED, Faculty of Health Sciences, Fernando Pessoa University, 4200-150 Porto, Portugal
3Molecular Virology Laboratory of Virology Service, Portuguese Institute of Oncology of Porto, Road Dr. António Bernardino Almeida, 4200-072 Porto, Portugal
4ICBAS, Abel Salazar Institute for the Biomedical Sciences, University of Porto, 4099-003 Porto, Portugal
5CEQUIMED, Faculty of Pharmacy, University of Porto, 4050-047 Porto, Portugal
6LPCC, Liga Portuguesa Contra O Cancro, Nucleo Regional do Norte, 4200-177 Porto, Portugal

Received 5 September 2011; Accepted 13 October 2011

Academic Editor: Michael Carducci

Copyright © 2011 Jani Silva et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

This study aimed to characterize the HPV infection status in adolescents and young university women in Portugal. The distribution of HPV genotypes was evaluated by PCR DNA genotyping after self-sampling collection from 435 women of exfoliated cervical cells using a commercial kit. We observed an overall frequency of HPV infection of 11.5%. Furthermore, HPV DNA prevalence was 16.6% in those young women that self-declared as sexually active. The more frequently detected HPV types were 31, 16, 53, and 61. Statistical analysis identified median age ( ; ), the number of lifetime sexual partners ( ; ), and years of sexual activity ( ; ) as risk factors for HPV acquisition. Hence, our study revealed that oncogenic HPV infection is common in young asymptomatic women Portuguese women, with a history of 2–5 sexual partners and over 2 year of sexual activity. Moreover, these results demonstrate that HPV detection performed in self-collected samples may be important to appraise better preventive strategies and to monitorize the influence of vaccination programmes within different populations.