Research Article
A Cohort Study of p53 Mutations and Protein Accumulation in Benign Breast Tissue and Subsequent Breast Cancer Risk
Table 3
Baseline characteristics of the study subjects.
| | Variable | Cases () | Controls () | value* | | | (%) | | (%) | |
| | Age at biopsy | | | | | | | <40 | 109 | (22.2) | 105 | (22.3) | | | 40 to <50 | 169 | (34.4) | 166 | (35.2) | | | 50 to <60 | 107 | (21.8) | 102 | (21.7) | | | 60 to <70 | 69 | (14.1) | 62 | (13.2) | | | ≥70 | 37 | (7.5) | 36 | (7.6) | 0.99 | | Histology | | | | | | | Nonproliferative disease | 137 | (27.9) | 173 | (36.7) | | | Proliferative disease | | | | | | | without atypia | 322 | (65.6) | 289 | (61.4) | | | Proliferative disease | | | | | | | with atypia | 32 | (6.5) | 9 | (1.9) | | | Age at menarche | | | | | | | <12 | 76 | (20.0) | 74 | (19.5) | | | 12 | 87 | (22.9) | 77 | (20.3) | | | 13 | 109 | (28.7) | 116 | (30.5) | | | ≥14 | 108 | (28.4) | 113 | (29.7) | 0.80 | | Missing | 111 | | 91 | | | | Age at first live birth | | | | | | | Nulliparous | 95 | (21.9) | 73 | (17.3) | | | ≥30 | 58 | (13.4) | 34 | (8.1) | | | 25–<30 | 88 | (20.3) | 96 | (22.8) | | | 20–<25 | 150 | (34.6) | 177 | (41.9) | | | <20 | 43 | (9.9) | 42 | (10.0) | 0.02 | | Missing | 57 | | 49 | | | | Parity | | | | | | | Nulliparous | 95 | (19.3) | 73 | (15.4) | | | Parous | 392 | (79.8) | 391 | (83.0) | 0.13 | | Missing | 4 | | 7 | | | | Number of pregnancies | | | | | | | None | 95 | (19.8) | 73 | (16.3) | | | 1 | 80 | (16.4) | 69 | (14.8) | | | 2 | 152 | (31.1) | 157 | (33.6) | | | 3 | 83 | (17.0) | 91 | (19.5) | | | ≥4 | 77 | (15.7) | 74 | (15.8) | 0.83 | | Missing | 4 | | 7 | | | | Menopausal status | | | | | | | Premenopausal | 264 | (53.8) | 237 | (57.0) | | | Perimenopausal | 39 | (7.9) | 34 | (7.2) | | | Postmenopausal | 188 | (38.3) | 200 | (38.3) | 0.27 | | Ever used hormone therapy | | | | | | | No | 350 | (71.3) | 317 | (67.3) | | | Yes | 141 | (28.7) | 154 | (32.7) | 0.18 | | Family history of breast cancer in a first-degree relative | | | | | | | No | 386 | (82.7) | 394 | (83.8) | | | Yes | 81 | (17.3) | 57 | (12.0) | 0.05 | | Missing | 24 | | 20 | | |
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*Based on likelihood-ratio-chi-square test.
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