Journal of Oncology / 2011 / Article / Tab 3

Research Article

A Cohort Study of p53 Mutations and Protein Accumulation in Benign Breast Tissue and Subsequent Breast Cancer Risk

Table 3

Baseline characteristics of the study subjects.

VariableCases ( )Controls ( ) value*
(%) (%)

Age at biopsy
 <40109(22.2)105(22.3)
 40 to <50169(34.4)166(35.2)
 50 to <60107(21.8)102(21.7)
 60 to <7069(14.1)62(13.2)
 ≥7037(7.5)36(7.6)0.99
Histology
 Nonproliferative disease137(27.9)173(36.7)
 Proliferative disease
  without atypia322(65.6)289(61.4)
 Proliferative disease
  with atypia32(6.5)9(1.9)
Age at menarche
 <1276(20.0)74(19.5)
 1287(22.9)77(20.3)
 13109(28.7)116(30.5)
 ≥14108(28.4)113(29.7)0.80
 Missing11191
Age at first live birth
 Nulliparous95(21.9)73(17.3)
 ≥3058(13.4)34(8.1)
 25–<3088(20.3)96(22.8)
 20–<25150(34.6)177(41.9)
 <2043(9.9)42(10.0)0.02
 Missing5749
Parity
 Nulliparous95(19.3)73(15.4)
 Parous392(79.8)391(83.0)0.13
 Missing47
Number of pregnancies
 None95(19.8)73(16.3)
 180(16.4)69(14.8)
 2152(31.1)157(33.6)
 383(17.0)91(19.5)
 ≥477(15.7)74(15.8)0.83
 Missing47
Menopausal status
 Premenopausal264(53.8)237(57.0)
 Perimenopausal39(7.9)34(7.2)
 Postmenopausal188(38.3)200(38.3)0.27
Ever used hormone therapy
 No350(71.3)317(67.3)
 Yes141(28.7)154(32.7)0.18
Family history of breast cancer in a first-degree relative
 No386(82.7)394(83.8)
 Yes81(17.3)57(12.0)0.05
 Missing2420

*Based on likelihood-ratio-chi-square test.

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