Journal of Oncology

Research Article

A Cohort Study of p53 Mutations and Protein Accumulation in Benign Breast Tissue and Subsequent Breast Cancer Risk

Table 4

p53 immunopositivity in benign breast tissue and risk of breast cancer.


Variable	Level	No. of cases	No. of controls	OR (95% CI)	OR (95% CI)

Immunopositive	Absent	370	345	1.0 (reference)	1.0 (reference)
	Present	83	86	0.95 (0.62–1.44)	0.88 (0.57–1.37)
	Missing	38	40
% cells immunopositive
	0	370	345	1.00 (reference)	1.00 (reference)
	>0–<1	42	39	1.25 (0.69–2.26)	1.27 (0.68–2.35)
	1–9	30	37	0.75 (0.40–1.39)	0.68 (0.36–1.32)
	≥10	11	10	0.74 (0.26–2.10)	0.57 (0.20–1.64)
	Missing	38	40

Adjusted for center, age at enrollment, and years of followup.
Adjusted for age at enrollment, center (city), years of followup, histology (nonproliferative, proliferative disease), family history (no, yes), age at menarche (<12,12,13,14–19), age at first birth (continuous), number of pregnancies (continuous), and menopausal status (premenopausal, perimenopausal, postmenopausal).