A Cohort Study of p53 Mutations and Protein Accumulation in Benign Breast Tissue and Subsequent Breast Cancer Risk
Table 5
Association of p53 exonic changes in DNA extracted from benign breast tissue and breast cancer.
Type of exonic change
Level
No. of cases
No. of controls
OR (95% CI)
OR (95% CI)
Any change
Wild type
301
294
1.0
1.0
Present
24
25
1.46 (0.60–3.56)
1.03 (0.40–2.65)
Missing
166
152
Deletions
Wild type
301
294
NA
NA
Present
0
0
Missing
190
177
Insertions
Wild type
301
294
NA
NA
Present
0
0
Missing
190
177
Nonsense mutations
Wild type
301
294
NA
NA
Present
0
1
Missing
190
176
Missense mutations
Wild type
301
294
1.0
1.0
Present
17
15
2.42 (0.89–7.29)
1.47 (0.48–4.52)
Missing
173
162
Silent mutations
Wild type
301
294
NA
NA
Present
0
1
Missing
190
176
Splice site mutations
Wild type
301
294
NA
NA
Present
0
0
Missing
190
177
Polymorphism
Wild type
301
294
1.0
1.0
Present
7
7
0.59 (0.12–2.86)
0.47 (0.08–2.96)
Missing
183
170
NA: not applicable. Adjusted for center, age at enrollment, and years of followup. Adjusted for age at enrollment, center (city), years of followup, histology (nonproliferative, proliferative disease), family history (no, yes), age at menarche (<12,12,13,14–19), age at first birth (continuous), number of pregnancies (continuous), and menopausal status (premenopausal, perimenopausal, postmenopausal).
