Journal of Oncology / 2011 / Article / Tab 5

Research Article

A Cohort Study of p53 Mutations and Protein Accumulation in Benign Breast Tissue and Subsequent Breast Cancer Risk

Table 5

Association of p53 exonic changes in DNA extracted from benign breast tissue and breast cancer.

Type of exonic change Level No. of cases No. of controls OR (95% CI) OR (95% CI)

Any change Wild type3012941.01.0
Present24251.46 (0.60–3.56) 1.03 (0.40–2.65)
Missing166152

Deletions Wild type301294 NA NA
Present00
Missing190177

Insertions Wild type301294 NA NA
Present00
Missing190177

Nonsense mutations Wild type301294 NA NA
Present01
Missing190176

Missense mutations Wild type3012941.01.0
Present1715 2.42 (0.89–7.29) 1.47 (0.48–4.52)
Missing173162

Silent mutations Wild type301294 NA NA
Present01
Missing190176

Splice site mutations Wild type301294 NA NA
Present00
Missing190177

Polymorphism Wild type3012941.01.0
Present77 0.59 (0.12–2.86) 0.47 (0.08–2.96)
Missing183170

NA: not applicable.
Adjusted for center, age at enrollment, and years of followup.
Adjusted for age at enrollment, center (city), years of followup, histology (nonproliferative, proliferative disease), family history (no, yes), age at menarche (<12,12,13,14–19), age at first birth (continuous), number of pregnancies (continuous), and menopausal status (premenopausal, perimenopausal, postmenopausal).

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