A Cohort Study of p53 Mutations and Protein Accumulation in Benign Breast Tissue and Subsequent Breast Cancer Risk

Table 6

Association of p53 protein accumulation and p53 nucleotide changes in benign breast tissue and risk of breast cancer.

p53 change	Level	No. of cases*	No. of controls*	ORa (95% CI)	ORb (95% CI)
Immunopositivity and/or nucleotide change	Both absent	235	227	1.0 (reference)	1.0 (reference)
	Immuno +, change −	65	63	1.17 (0.73–1.91)	1.10 (0.66–1.84)
	Immuno −, change +	21	23	1.35 (0.53–3.44)	0.89 (0.33–2.40)
	Immuno +, change +	3	2	5.60 (0.27–115.3)	4.79 (0.28–82.31)
	Missing	167	156

*38 cases/40 controls missing information on immunopositivity; 0 cases/0 controls missing information on nucleotide changes; 38 cases/40 controls missing information on combined variable.
aAdjusted for center, age at enrollment, and years of followup.
bAdjusted for age at enrollment, center (city), years of followup, histology (nonproliferative, proliferative disease), family history (no, yes), age at menarche (<12,12,13,14–19), age at first birth (continuous), number of pregnancies (continuous), and menopausal status (premenopausal, perimenopausal, postmenopausal).