Folate and Colorectal Cancer in Rodents: A Model of DNA Repair Deficiency

Table 3

Impact of dietary intervention on blood and colon folate status.

Percent change in blood folate status by dietary intervention
2 mg/kg to 0 mg/kg	↓96%	Rat	20 wk
(with either abx or wire bottom cages)	↓96%	Rat	11 wk
	↓92%	Mouse	8 wk
[21, 75, 76, 83, 85]	↓50%	Rat	8 wk
	↓81%	Rat	24 wk
2 mg/kg to 0 mg/kg	↓69%	Mouse	12 wk
(without abx or wire bottom cages)	↓63%*	Mouse	5 wk
	↓78%*	Mouse	11 wk
[68, 77, 84]	↓35%**	Mouse	16 wk
2 mg/kg to 8 mg/kg	↑58%	Rat	20 wk
(with either abx or wire bottom cages)	↑62%	Rat	8 wk
[75, 76, 83]	↑140%	Rat	24 wk
2 mg/kg to 8 mg/kg
(without abx or wire bottom cages)	↑44%	Mouse	12 wk
[77]
Percent change in colon folate status by dietary intervention
2 mg/kg to 0 mg/kg	↓72%	Rat	20 wk
(with either abx or wire bottom cages)	↓35%	Rat	8 wk
[75, 83]
2 mg/kg to 0 mg/kg	↓74%*	Mouse	5 wk
(without abx or wire bottom cages)	↓40%**	Mouse	16 wk
[68, 84]
2 mg/kg to 8 mg/kg	↑19%	Rat	20 wk
(with either abx or wire bottom cages)	↑66%	Rat	8 wk
[75, 83]
2 mg/kg to 8 mg/kg
(without abx or wire bottom cages)

Abx: antibiotics; wk: week; *choline also depleted in this dietary intervention; **riboflavin, B6, and B12 also modified in this dietary intervention.