The Role of PTEN in Tumor Angiogenesis

Table 2

Clinical trials having shown an impact of the PTEN status on the response to cancer treatment.

Type of cancer	Metastatic form	Treatments	References
Colorectal		Cetuximab, panitumab	[66–69]
	×	Cetuximab (+irinotecan)	[70–72]
Breast		Trastuzumab, lapatinib	[73–76]
	×	Trastuzumab	[76–78]
		Endocrine therapy
Glioblastoma		Gefitinib, erlotinib	[79–81]
		Erlotinib + temozolomid
Gastric		Streptozotocin, doxorubicin, 5-fluorouracil, etoposide/cisplatinum	[82, 83]
	×	Streptozotocin, doxorubicin	[82]
Lung		Gefitinib, erlotinib	[84, 85]
	×	Gefitinib, erlotinib	[85]
Pancreas		Gemcitabine	[62]
Esophageal		5-fluoropyrimidine, taxane, platinum, PI3K pathway inhibitor	[86]